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Are you taking an antibiotic?
...take a synbiotic

Used once daily
preferably
at bedtime
The product
does not need
to be refrigerated
The product
does not contain
milk, casein or lactose

For the healthy stomach
of your baby

Used once daily
preferably
at bedtime
The product
does not need
to be refrigerated
The product
does not contain
milk, casein or lactose

Are you taking an antibiotic?
...take a synbiotic

Used once daily
preferably
at bedtime
The product
does not need
to be refrigerated
The product
does not contain
milk, casein or lactose

MULTILAC® is a modern synbiotic that contains nine selected bacterial strains and a nutritive component - oligofructose.

Due to the use of an innovative MURE® technology (Multi Resistant Encapsulation), bacteria in the MULTILAC® product exhibit higher resistance to low pH of the gastric juice, bile salts and digestive enzymes. This enables their adaptation and maintenance of high biological activity. A nutritive component of the MULTILAC® synbiotic is an energy source required for bacteria development that enables their more rapid proliferation in the gastrointestinal tract. MULTILAC® does not contain milk, lactose or casein.

Supportive, during and after an antibiotic therapy, in the periods of increased susceptibility to infections.

Adults: Take 1 capsule once daily (preferably at bedtime). Children: Give 1 capsule once daily (preferably at bedtime). MULTILAC® can be used in children who are able to swallow a capsule. Do not exceed the recommended daily dose. Dietary supplement. May not be used as a substitute for the balanced diet.

An active substance Contents per 1 caps.
Bacterial lyophilizate belonging to 9 different strains: 4,5 miliarda bakterii (4,50 x 109 CFU*)
Lactobacillus helveticus 9,00 x 108 CFU
Lactococcus lactis 9,00 x 108 CFU
Bifidobacterium longum 6,75 x 108 CFU
Bifidobacterium breve 4,50 x 108 CFU
Lactobacillus rhamnosus 4,50 x 108 CFU
Streptococcus thermophilus 4,50 x 108 CFU
Bifidobacterium bifidum 2,25 x 108 CFU
Lactobacillus casei 2,25 x 108 CFU
Lactobacillus plantarum 2,25 x 108 CFU
A nutritive ingredient - oligofruktoza 63 mg
 
* Colony Forming Unit - a unit forming bacterial colony

Intestinal microflora

What is the intestinal microflora
and what is its function?

The intestinal microflora is composed of approximately 500-1000 microorganism species. They include anaerobic and aerobic microorganisms. They can be classified as beneficial and pathogenic ("bad").

The adequately balanced intestinal microflora is responsible for e.g.:

Beneficial bacteria support normal peristalsis, prevent diarrhea, constipation and bloating.

By permanently colonizing the intestines, they reduce the risk of adherence of „bad” bacteria to the mucosa. They are able to produce such substances as lactic acid, hydrogen peroxide and specific peptides that inhibit or even kill many pathogenic gastrointestinal bacteria, fungi and yeasts.

Some “good” bacteria are able to produce compounds that facilitate digestion of unabsorbable substances, e.g. Streptococcus thermophilus produces B- galactosidase, an enzyme that facilitates lactose digestion.

What disturbs
the intestinal microflora?

Symptoms of drastic reduction of lactic acid bacteria count:

  • Abdominal pain
  • Constipation, bloating
  • Diarrhea
  • Indigestion
  • Hyperacidity
  • Food allergies

Situation resulting in disturbed balance of the intestinal microflora:

  • Intake of antibiotics
  • Infections
  • Improper diet
  • Change of diet (especially during travels)
  • Stress
  • Age - aging

A synbiotic that is close to an ideal one

Synbiotic = live bacterial cultures
+ nutritive ingredient

A synbiotic is a combination of live bacterial cultures with a nutritive ingredient. Synbiotics facilitate restoration of normal gastrointestinal microflora.

Does the formulation that you use meet requirements of a probiotic that is close to an ideal one?

is resistant to effects of
hydrochloric acid

due to the use of an innovative MURE® encapsulation technlogoy, it provides better survival of bacteria versus other commerically available products that contain live bacterial strains*

exhibits high ability of adhesion to the intestinal epithelial cells

as a combination of 9 bacterial strains exhibits higher ability to colonize the intestinal epithelium than single bacterial strains **

is characterized by ability to rapid growth and prliferation

due to the contents of the biggest number of bacterial strains and nutritive substances that stimulate their growth ***

which makes a product CLOSE TO AN IDEAL ONE

* A comparative in vitro study of stability and disintegration of capsules manufactured using the MURE® (Multi Resistant Encapsulation) technology versus other capsules that contain probiotics, under conditions mimicking gastric environment. Jacek Piątek, M.D., Ph.D. Department of Human Physiology, Karol Marcinkowski Medical University of Poznań ** Determination of adhesive abilities of bacteria included in a combined probiotic formulation to cultured intestinal epithelium Caco-2. Jacek Piątek, M.D., Ph.D. Department of Human Physiology, Karol Marcinkowski Medical University of Poznań *** A comparative in vitro growth kinetic testing of bacterial colonies included in MULTILAC® with selected commercially available probiotics. Jacek Piątek, M.D., Ph.D. Department of Human Physiology, Karol Marcinkowski Medical University of Poznań.

What are the beneficial bacteria?

The most popular strains include:

  • Bacterial strains that produce lactic acid: Lactobacillus, Bifidobacterium, Streptococcus
  • Nonpathogenic yeast strains Saccharomyces boulardii.
What does effectiveness of bacteria depend on?

Effectiveness of bacteria depends on the following factors:

  • CFU (colony forming units) contents of bacterial strains per 1 capsule
  • Use of technology for bacterial protection from detrimental effects of hydrochloric acid in the stomach

Minimum therapeutic daily dose of live bacteria is 106-109 CFU .

Prof. Hanna Szajewska
Medical University of Warsaw
Department of Pediatrics

What are the nutritive substances?

Indigestible food components that selectively stimulate growth or activity of selected gastrointestinal bacterial strains and through beneficial change of their composition contribute to improvement of host’s health

GR.Gibson, M. Roberfroid .J. Nutr. 1995:125:1401-12

What are
live bacterial
cultures?

Live bacterial cultures are selected strains of good bacteria that, when ingested, support normal function of the gastrointestinal tract.

Definition according to FAO/WHO
Live microorganisms that, when given in adequate amounts, have beneficial health effects.

Definition by Fuller.: Gut 1991; 32: 439-42
Live microorganisms that, when ingested, have beneficial effects on the host by improving balance of the intestinal microflora.

Innovative MURE® Technology

Multi Resistant Encapsuation

Encapsulation
technology

An innovative encapsulation technology used in MULTILAC® involves covering of a capsule with a special protective coating that makes the bacteria in the product more resistant to low pH of gastric juice, bile salts and digestive enzymes. The encapsulation increases bacterial survival in the gastrointestinal tract. It enables their better adaptation (colonization – proliferation) in the intestines, which guarantees high biological activity and effectiveness of live bacterial strains included in MULTILAC®.

Thanks to the MURE® technology, effectiveness of MULTILAC ® is higher than that of other commercially available products that contain live bacterial strains.

Is it worth it to use synbiotics with special protective technology?

Bacteria are very sensitive to adverse environmental conditions (e.g. moisture, high temperature). They are also susceptible to adverse conditions of the gastrointestinal tract. When subjected to digestive enzymes, bile salts or low pH of gastric juice, bacteria lose their activity and their effectiveness is low.

MURE® technology used in MULTILAC® protects the live bacterial strains from destructive effects of hydrochloric acid, therefore, contributing to better intestinal colonization by microorganisms.

MURE® Technology:
  • that probiotic bacteria are delivered to the intestine without any loses
  • impreoved stability and higher efficacy of probiotics

Does the number of strains
included in the product matter?

Intestinal flora exhibits interindividual variability, since it is affected by multiple environmental and genetic factors. Each of bacterial strains has its unique properties and determines effectiveness in other medical conditions. Intestinal flora exhibits interindividual variability and thus by using a product that contains as many as 9 bacterial strains it is easier to supplement it in majority of subjects.

Composition – Lyophilizate of bacteria belonging to 9 different strains:

Lactobacillus rhamnosus:

  • protection from antibiotic-induced diarrheas
  • support and prevention of rotavirus-induced diarrheas
  • in recurrent diarrheas induced by Clostridium difficile
  • protection from acute diarrheas
  • stimulation of the immune system

Lactobacillus casei:

  • protection from intestinal disorders
  • in rotavirus-induced diarrheas
  • in constipation

Lactobacillus plantarum:

  • alleviation of complaints caused by the irritable bowel syndrome
  • prophylaxis of recurrences of nonspecific inflammatory bowel disease

Lactobacillus helveticus:

  • probiotic with high resistance to gastric acid
  • due to produced bacteriocins, inhibits development of detrimental bacterial flora and alleviates lactose intolerance
  • prevents, reduces diarrhea duration

Lactococcus lactis:

  • due to produced bacteriocins – inhibits development of detrimental bacterial flora

Bifidobacterium longum:

  • prevention of travelers’ diarrheas
  • prophylaxis of recurrences of nonspecific inflammatory bowel disease

Bifidobacterium bifidum:

  • prevention of rotavirus-induced diarrheas

Bifidobacterium breve:

  • maintenance of balance of the intestinal microflora
  • protection from diarrheas
  • prophylaxis of recurrences of nonspecific inflammatory bowel disease

Streptococcus thermophilus:

  • protection from and alleviation of rotavirus-induced diarrheas
  • prevention of travelers’ diarrheas
  • alleviates lactose intolerance

FAQ

Live bacterial strains facilitate maintenance of normal function of the gastrointestinal tract and therefore their use has beneficial effects on health of a subject who takes beneficial bacteria.

Antibiotics are an effective tool to fight bacterial infections, but they are no use in fighting viruses, which are insensitive to them.

Antibiotics can cure multiple dangerous disease, but concurrently, they reduce immunity and cause problems, e.g. with the gastrointestinal tract.

Studies have demonstrated that live bacterial strains require approximately 4 weeks after the end of antibiotic therapy to re-colonize the intestines. Complete restoration of the bacterial flora may take even 6 months! Therefore, it is not proper to impair your health during an antibiotic therapy and wait for the beneficial bacteria to form a powerful protective barrier in the intestines from various microorganisms. It is recommnded to take products that contain live bacterial strains concomitantly with an antibiotic therapy. They contain beneficial bacteria Lactobacillus and Bifidobacterium. They protect the intestines from pathogenic microorganisms and stimulate function of the immune system. They prevent diarrheas and impairment of immunity related to an antibiotic therapy. You should remember to use them for as long as 5-7 days after the end of your antibiotic therapy.

You should pay attention to products that contain nutritive substances for live bacterial strains (e.g. oligofructose). Such product is referred to as a synbiotic and exhibits particularly beneficial effects, since adequately nourished beneficial bacteria will colonize the gastrointestinal tract and proliferate more rapidly. Therefore, they will protect the host from bad bacteria more effectively and will have beneficial effects on intestinal motility, preventing both diarrhea as well as constipation.

Traditional products that contain live bacteria MULTILAC®
No capsule protection technology – some live bacteria are inactivated by hydrochloric acid in the stomach – lower effectiveness of the product The innovative MURE® encapsulation technology provides survival of probiotic bacteria in the environment of low pH of gastric hydrochloric acid, allows probiotic to reach the intestines, the site of its actual activity
Only live bacteria Synbiotic = live bacteria + nutritive substance (a substance that is a nutriment for probiotic) – better bacterial development
Low number of bacterial strains, selective effects, need to administer several doses daily Large number – 9 live bacterial strains, accounting for variable composition of the intestinal flora in each human
The product contains allergic substances (e.g. cow’s milk proteins) The product does not contain milk, lactose or casein - SAFE FOR ALLERGIC PATIENTS
Most of the products need to be refrigerated The product is resistant to moisture and atmospheric oxygen – DOES NOT NEED TO BE REFRIGERATED

Using a synbiotic provides particular benefits, since apart from live bacteria, the synbiotic contains also a nutritive ingredient (oligofructose in MULTILAC®). A nutritive substance is a precious source of energy needed for bacterial development. It provides adequate conditions for proliferation and high activity of beneficial bacteria. Synbiotics (including Multilac) restore and maintain normal composition of the gastrointestinal microflora. Use of a synbiotic provides particular benefits, since apart from live bacteria, the synbiotic contains also a nutrient for beneficial bacteria. Synbiotics protect the host from bad bacteria more effectively than bacteria alone, they protect us from antibiotic-associated diarrhea, have beneficial effects on intestinal peristalsis, prevent both diarrhea and constipation. Studies demonstrate that bacteria require approximately 4 weeks to re-colonize the intestines after the end of an antibiotic therapy. Complete restoration of the bacterial flora may take even 6 months!